EULAR Recommendations: Recommendations for Conducting and Reporting Clinical Trials

Following is a list of EULAR Recommendations for conducting / reporting clinical trials, dating back to 2006. Scroll down the page for the full overview:



2023

Alen Zabotti, Gabriele De Marco, Laure Gossec , Xenofon Baraliakos, Daniel Aletaha, Annamaria Iagnocco,  Paolo Gisondi, Peter V Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Nemanja S Damjanov, Maarten de Wit, Enzo Errichetti, Helena Marzo-Ortega, Mikhail Protopopov, Lluis Puig, Rubén Queiro, Piero Ruscitti, Laura Savage, Georg Schett, Stefan Siebert, Tanja A Stamm, Paul Studenic, Ilaria Tinazzi, Filip E Van den Bosch, Annette van der Helm-van Mil, Abdulla Watad, Josef S Smolen, Dennis G McGonagle
 
2023 EULAR points to consider for the definition of clinical and imaging features suspicious for progression from psoriasis to psoriatic arthritis
 
 
Annals of the Rheumatic Diseases Published Online First: 09 June 2023. doi: 10.1136/ard-2023-224148

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Javier Rodríguez-Carrio, Agata Burska, Philip G Conaghan, Willem A Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Frémond, Mary K Crow, Lars Rönnblom, Marjan A Versnel, Edward M Vital

2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice


Annals of the Rheumatic Diseases Published Online First: 01 March 2023. doi: 10.1136/ard-2022-223628

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SLR 1

SLR 2 


2022


George E Fragoulis, Elena Nikiphorou, Mrinalini Dey, Sizheng Steven Zhao, Delphine Sophie Courvoisier, Laurent Arnaud, Fabiola Atzeni, Georg MN Behrens, Johannes WJ Bijlsma, Peter Böhm, Costas A Constantinou, Silvia Garcia-Diaz, Meliha Crnkic Kapetanovic, Kim Lauper, Mariana Luís, Jacques Morel, György Nagy, Eva Poleverino, Jef van Rompay, Marco Sebastiani, Anja Strangfeld, Annette de Thurah, James Galloway, Kimme L Hyrich

2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases

Published Online First: 03 November 2022. doi: 10.1136/ard-2022-223335

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Paul Studenic, Tanja A Stamm, Erika Mosor, Ilaria Bini, Nele Caeyers, Laure Gossec, Marios Kouloumas, Elena Nikiphorou, Wendy Olsder, Ivan Padjen, Sofia Ramiro, Simon Stones, Tanita-Christina Wilhelmer and Alessia Alunno

Development of EULAR points to consider/recommendations for including the perspective of young patients with inflammatory arthritis into patient-reported outcomes measures


First published July 29, 2022. RMD Open 2022;8:e002576. doi: 10.1136/rmdopen-2022-002576

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Silvia Magni-Manzoni, Valentina Muratore, Jelena Vojinović, Denise Pires Marafon, Maria Antonietta D'Agostino, Esperanza Naredo 

Guide/Recommendations for The Conduct, Content and Format of EULAR/PReS Paediatric Musculoskeletal Ultrasound Courses
 
First published July 7, 2022. RMD Open 2022;8:e002455. doi: 10.1136/rmdopen-2022-002455
 
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Aurélie Najm, Félicie Costantino, Stefano Alivernini, Alessia Alunno, Elettra Bianchi, Jacqueline Bignall, Brendan Boyce, Juan D Cañete, Francesco Carubbi, Patrick Durez, João Eurico Fonseca, Søren Andreas Just, Raquel Largo, Antonio Manzo, Mark Maybury, Esperanza Naredo, Carl Orr, Costantino Pitzalis, Felice Rivellese, Vasco C Romão, Jef van Rompay, Sander W Tas, Douglas J Veale, Maria-Antonietta D'Agostino, Andrew Filer
 
EULAR points to consider for minimal reporting requirements in synovial tissue clinical applications and research in rheumatology

 
Published Online First: 24 February 2022. Annals of the Rheumatic Diseases doi: 10.1136/annrheumdis-2021-221875
 
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Delphine Sophie Courvoisier, kim Lauper, Joanna Kedra, Maarten de Wit, Bruno Fautrel, Thomas Frisell, Kimme L Hyrich, Florenzo Iannone, Pedro M Machado, Lykke Midtbøll Ørnbjerg, Ziga Rotar, Maria Jose Santos, Tanja A Stamm, Simon R Stones, Anja Strangfeld, Sytske Anne Bergstra, Robert B M Landewé, Axel Finckh
 
EULAR points to consider when analysing and reporting comparative effectiveness research using observational data in rheumatology
 
Published Online First: 20 January 2022. doi: 10.1136/annrheumdis-2021-221307
 
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2021


Christian Dejaco, Pedro M Machado, Francesco Carubbi, Philipp Bosch, Lene Terslev, Giorgio Tamborrini, Luca Maria Sconfienza, Carlo Alberto Scirè, Sebastian Ruetten, Jef van Rompay, Fabian Proft, Costantino Pitzalis, Marina Obradov, Rikke Helene Moe, Vasco V Mascarenhas, Clara Malattia, Andrea Sabine Klauser, Alison Kent, Lennart Jans, Wolfgang Hartung, Hilde Berner Hammer, Christina Duftner, Peter V Balint, Alessia Alunno, Xenofon Baraliakos

EULAR recommendations for the use of imaging to guide interventional procedures in patients with Rheumatic and Musculoskeletal Diseases (RMD)


First published December 10, 2021. Annals of the Rheumatic Diseases 2022;81:760-767

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Kulveer Mankia, Heidi J Siddle, Andreas Kerschbaumer, Deshire Alpizar Rodriguez, Irinel Catrina, Juan D Cañete, Andrew P Cope, Claire Immediato Daien, Kevin D Deane, Hani El Gabalawy, Axel Finckh, V Michael Holers, Marios Koloumas, Francesca Ometto, Karim Raza, Condruta Zabalan, Annette van der Helm-van Mil, Dirkjan van Schaardenburg, Daniel Aletaha, Paul Emery
 
EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis

 
Published Online First: 06 August 2021. doi: 10.1136/annrheumdis-2021-220884
 
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Félicie Costantino, Loreto Carmona, Maarten Boers, Marina Backhaus, Peter V Balint, George A Bruyn, Robin Christensen, Philip G Conaghan, Ricardo J O Ferreira, Juan Luis Garrido-Castro, Francis Guillemin, Hilde Berner Hammer, Désirée van der Heijde, Annamaria Iagnocco, Marion C Kortekaas, Robert BM Landewé, Peter Mandl, Esperanza Naredo, Wolfgang A Schmidt, Lene Terslev, Caroline B Terwee, Ralf Thiele, Maria-Antonietta D'Agostino
 
EULAR recommendations for the reporting of ultrasound studies in rheumatic and musculoskeletal diseases (RMDs) 

 
Published Online First: 22 January 2021. doi: 10.1136/annrheumdis-2020-219816
 
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2020

Yvette Meissner, Rebecca Fischer-Betz, Laura Andreoli, Nathalie Costedoat-Chalumeau, Diederik De Cock, Radboud J E M Dolhain, Frauke Forger, Doreen Goll, Anna Molto, Catherine Nelson-Piercy, Rebecca Özdemir, Luigi Raio, Sebastian Cruz Rodríguez-García, Savino Sciascia, Marianne Wallenius, Astrid Zbinden, Angela Zink, Anja Strangfeld

EULAR recommendations for a core data set for pregnancy registries in rheumatology 


Published Online First: 14 October 2020. Annals of the Rheumatic Diseases 2021;80:49-56

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2019

Laure Gossec, Joanna Kedra, Hervé Servy, Aridaman Pandit, Simon Stones, Francis Berenbaum, Axel Finckh, Xenofon Baraliakos, Tanja A Stamm, David Gomez-Cabrero, Christian Pristipino, Remy Choquet, Gerd R Burmester, Timothy R D J Radstake

EULAR points to consider for the use of big data in rheumatic and musculoskeletal diseases


Published Online First: 22 June 2019. doi: 10.1136/annrheumdis-2019-215694

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2018

Helga Radner, Katerina Chatzidionysiou, Elena Nikiphorou, Laure Gossec, Kimme L Hyrich, Condruta Zabalan, Yvonne van Eijk-Hustings, Paula R. Williamson, Andra Balanescu, Gerd R. Burmester, Loreto Carmona, Maxime Dougados, Axel Finckh, Glenn Haugeberg, Merete Lund Hetland, Susan Oliver, Duncan Porter, Karim Raza, Patrick Ryan, Maria Jose Santos, Annette van der Helm-van Mil, Piet van Riel, Gabrielle von Krause, Jakub Zavada, William G Dixon, Johan Askling

EULAR recommendations for a core data set to support observational research and clinical care in rheumatoid arthritis                                                                           

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2017

Jelena Vojinovic, Angela Tincani, Alberto Sulli, Stefano Soldano, Laura Andreoli, Francesca Dall'Ara, Ruxandra Ionescu, Katarina Simic Pasalic, Inete Balcune, Ivan Ferraz-Amaro, Małgorzata Tlustochowicz, Irena Butrimiene, Egle Punceviciene, Natalia Toroptsova, Simeon Grazio, Jadranka Morovic-Vergles, Pavol Masaryk, Kati Otsa, Miguel Bernardes, Vladimira Boyadzhieva, Fausto Salaffi, Maurizio Cutolo

European multicentre pilot survey to assess vitamin D status in rheumatoid arthritis patients and early development of a new Patient Reported Outcome questionnaire (D-PRO)

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2016


Athan Baillet, Laure Gossec, Loreto Carmona, Maarten de Wit,Yvonne van Eijk-Hustings, Heidi Bertheussen, Kent Alison, Mette Toft, Marios Kouloumas, Ricardo J O Ferreira, Susan Oliver, Andrea Rubbert-Roth,Sander van Assen, William G Dixon, Axel Finckh, Angela Zink, Joel Kremer, Tore K Kvien, Michael Nurmohamed, Desirée van der Heijde, Maxime Dougados

Points to consider for reporting, screening for and preventing selected comorbidities in chronic inflammatory rheumatic diseases in daily practice: a EULAR initiative


Ann Rheum Dis doi:10.1136/annrheumdis-2016-209233

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2015


Heidi A Zangi, Mwidimi Ndosi, Jo Adams, Lena Andersen, Christina Bode, Carina Boström, Yvonne van Eijk-Hustings, Laure Gossec, Jana Korandová, Gabriel Mendes, Karin Niedermann, Jette Primdahl, Michaela Stoffer, Marieke Voshaar, Astrid van Tubergen

EULAR recommendations for patient education for people with inflammatory arthritis

Annals of the Rheumatic Diseases 2015;74:954-962 - Published in print 1 June 2015

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Maya H Buch, Lucia Silva-Fernandez, Loreto Carmona, Daniel Aletaha, Robin Christensen, Bernard Combe, Paul Emery, Gianfranco Ferraccioli, Francis Guillemin, Tore K Kvien, Robert Landewe, Karel Pavelka, Kenneth Saag, Josef S Smolen, Deborah Symmons, Désirée van der Heijde, Joep Welling, George Wells, Rene Westhovens, Angela Zink, Maarten Boers
 
EULAR recommendations for the reporting of clinical trial extension studies in rheumatology
 
Ann Rheum Dis 2015;74:963-969 doi:10.1136/annrheumdis-2013-204948
Published 8 May 2015
 
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2014

Raphaèle Seror, Simon J Bowman, Pilar Brito-Zeron, Elke Theander, Hendrika Bootsma, Athanasios Tzioufas, Jacques-Eric Gottenberg, Manel Ramos-Casals, Thomas Dörner, Philippe Ravaud, Claudio Vitali, Xavier Mariette

EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide
RMD Open 2015;1:e000022 doi:10.1136/rmdopen-2014-00002

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2011


Christian Beyer, Jörg H W Distler, Yannick Allanore, Martin Aringer, Jérôme Avouac, Làszlo Czirjak, Maurizio Cutolo, Nemanja Damjanov, Francesco Del Galdo, Kim Fligelstone, Serena Guiducci, Otylia Kowal-Bielecka, Jacob  M van Laar, Marco Matucci-Cerinic, Ulf Müller-Ladner, Gabriela Riemekasten, Ingo H Tarner, Alan Tyndall, Ann Tyrrell Kennedy, Gabriele Valentini, Serena Vettori, Ulrich A Walker, Christopher Denton, Oliver Distler, the EUSTAR Biobanking Group

EUSTAR biobanking: recommendations for the collection, storage and distribution of biospecimens in scleroderma research

Ann Rheum Dis 2011;70:1178-1182 doi:10.1136/ard.2010.142489 Published Online First 1 February 2011

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M P T de Wit, S E Berlo, G J Aanerud, D Aletaha, J W Bijlsma, L Croucher, J A P Da Silva, B Glüsing, L Gossec, S Hewlett, M Jongkees, D Magnusson, M Scholte-Voshaar, P Richards, C Ziegler, T A Abma
 
European League Against Rheumatism recommendations for the inclusion of patient representatives in scientific projects

 
Ann Rheum Dis 2011;70:722-726 Published Online First: 20 January 2011
 
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2010


WG Dixon, L Carmona, A Finckh, ML Hetland, TK Kvien, R Landewe, J Listing, PJ Nicola, U Tarp, A Zink, J Askling

EULAR points to consider when establishing, analysing and reporting safety data of biologics registers in rheumatology

Ann Rheum Dis 2010 Sep;69 (9): 1596-602; Published Online First 4 June 2010

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2009


Marta Mosca, Chiara Tani, Martin Aringer, Stefano Bombardieri, Dimitrios Boumpas, Robin Brey, Ricard Cervera, Andrea Doria, David Jayne, Munther A Khamashta, Annegret Kuhn, Caroline Gordon, Michelle Petri, Ole Petter Rekvig, Matthias Schneider, Yaniv Sherer, Yehuda Shoenfeld, Josef S Smolen, Rosaria Talarico, Angela Tincani, Ronald F van Vollenhoven, Michael M Ward, Victoria P Werth, Loreto Carmona

EULAR Recommendations for monitoring systemic lupus erythematosus patients in clinical practice and in observational studies 

Ann Rheum Dis. Jul 2010; 69: 1269-1274; Published Online First: 5 November 2009

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2008


Macfarlane GJ, Pallewatte N, Paudyal P, Blyth FM, Coggon D, Crombez G, Linton S, Leino-Arjas P, Silman AJ, Smeets RJ, van der Windt D.

Task Force on Measurement of Work-related Psychosocial Risk Factors for Musculoskeletal Disorders

Evaluation of work-related psychosocial factors and regional musculoskeletal pain: results from a EULAR Task Force. Ann Rheum Dis 2009 Jun;68(6):885-91). Published Online First: 22 August 2008

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C Gordon, G K Bertsias, J P A Ioannidis, J Boletis, S Bombardieri, R Cervera, C Dostál, G Font, I-M Gilboe, F Houssiau, T WJ Huizinga, D Isenberg, C G M Kallenberg, M A Khamashta, J-C Piette, M Schneider, J S Smolen, G Sturfelt, A Tincani, R Van Vollenhoven and D T Boumpas

EULAR points to consider for conducting clinical trials in systemic lupus erythematosus


Ann Rheum Dis., April 2009; 68: 470 - 476.  Published Online First: 3 April 2008

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D Aletaha, R Landewe, T Karonitsch, J Bathon, M Boers, C Bombardier, S Bombardieri, H Choi, B Combe, M Dougados, P Emery, J Gomez-Reino, E Keystone, G Koch, T K Kvien, E Martin-Mola, M Matucci-Cerinic, K Michaud, J ODell, H Paulus, T Pincus, P Richards, L Simon, J Siegel, J S Smolen, T Sokka, V Strand, P Tugwell, D van der Heijde, P van Riel, S Vlad, R van Vollenhoven, M Ward, M Weinblatt, G Wells, B White, F Wolfe, B Zhang, A Zink, D Felson
 
Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations

 
Ann Rheum Dis., Oct 2008; 67: 1360 - 1364. Accepted 4 June 2008
 
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2006


B Hellmich, O Flossmann, W L Gross, P Bacon, J W Cohen-Tervaert,
L Guillevin, D Jayne, A Mahr, P A Merkel, H Raspe, D GI Scott, J Witter,
H Yazici and R A Luqmani

EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: Focus on ANCA-associated vasculitis

Ann Rheum Dis, May 2007; 66: 605 - 617. Published Online First: 14 December 2006

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